Bicyclic Peptide Based Lectinomimic
نویسندگان
چکیده
منابع مشابه
Cell-Permeable Bicyclic Peptide Inhibitors against Intracellular Proteins
Cyclic peptides have great potential as therapeutic agents and research tools but are generally impermeable to the cell membrane. Fusion of cyclic peptides with a cyclic cell-penetrating peptide produces bicyclic peptides that are cell-permeable and retain the ability to recognize specific intracellular targets. Application of this strategy to protein tyrosine phosphatase 1B and a peptidyl-prol...
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2,4:3,5-di-O-methylene-D-glucitol (Glux-diol) was used for the synthesis of poly(butylene 10 succinate) (PBS) copolyesters by melt polycondensation. Glux-diol possess a rigid bicyclic 11 asymmetric structure made of two fused 1,3-dioxane rings and two hydroxyl functions at the end 12 positions. Copolyesters were prepared over the whole range of compositions with molecular 13 weights varying fro...
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The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we report the crystal structure of a stapled bicyclic peptide inhibitor G7-B1 in complex with the G...
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ژورنال
عنوان ژورنال: Croatica Chemica Acta
سال: 2017
ISSN: 0011-1643,1334-417X
DOI: 10.5562/cca3295